Which route refers to administration via the rectum with absorption through the intestinal lining?

Which route refers to administration via the rectum with absorption through the intestinal lining?

• A. Rectal administration
• B. Transdermal
• C. Inhalation
• D. Buccal administration

Answer: (A)

Absorption across the mucous lining of the digestive tract defines this route. The rectal route places the drug into the rectum where it dissolves and passes through the rectal mucosa—the lining of the rectum, which is part of the intestinal lining—into the bloodstream. This makes the delivery via the rectal mucosa distinct from other methods that rely on the skin, lungs, or the inside of the cheek for absorption. Transdermal delivers through the skin, inhalation through the respiratory tract, and buccal administration through the cheek lining. Therefore, the description fits rectal administration.

Absorption across the mucous lining of the digestive tract defines this route. The rectal route places the drug into the rectum where it dissolves and passes through the rectal mucosa—the lining of the rectum, which is part of the intestinal lining—into the bloodstream. This makes the delivery via the rectal mucosa distinct from other methods that rely on the skin, lungs, or the inside of the cheek for absorption. Transdermal delivers through the skin, inhalation through the respiratory tract, and buccal administration through the cheek lining. Therefore, the description fits rectal administration.